週次 |
日期 |
單元主題 |
第1週 |
3/03 |
Introduction (陳基旺) |
第2週 |
3/10 |
Enzymes I: basic binding and catalysis (孔繁璐) |
第3週 |
3/17 |
Enzymes II: steady-state kinetic analysis, competitive, uncompetitive inhibition(孔繁璐) |
第4週 |
3/24 |
Drug design I: Learn from history (梁碧惠) |
第5週 |
3/31 |
Drug designs II: a. Lead optimization: bioisosteres, conformation restriction ; b. SAR: molecular variation in homologues series and ring transformation (梁碧惠) |
第6週 |
4/07 |
Receptors: a. Binding theory and types of binding; b. Ion channels, G-protein coupled receptors (梁碧惠) |
第7週 |
4/14 |
Midterm Exam (陳(8%)、孔(15%)、梁(21%)) |
第8週 |
4/21 |
General concept of drug like property (忻凌偉) |
第9週 |
4/28 |
Lipophilicity, pKa, permeability, solubility (忻凌偉) |
第10週 |
5/05 |
Transporters, BBB, stability, protein binding (忻凌偉) |
第11週 |
5/12 |
Prodrug strategy (忻凌偉) |
第12週 |
5/19 |
Metabolism and toxicity (梁碧惠) |
第13週 |
5/26 |
Enzyme inhibitor designs: reversible enzyme inhibitors and approaches (梁碧惠) |
第14週 |
6/02 |
Enzyme inhibitor designs: irreversible enzyme inhibitors and approaches (梁碧惠) |
第15週 |
6/09 |
Special topic: new strategy in drug design (忻凌偉) |
第16週 |
6/16 |
Final Exam (忻(35%)、梁(21%)) |